Similarly, the ELIXA (evaluation of cardiovascular outcomes in patients with type 2 diabetes after acute coronary syndrome during treatment with lixisenatide) trial, which examined the GLP-1 agonist lixisenatide versus placebo in patients with T2DM and a history of recent acute coronary syndrome, found a neutral effect of the drug on adverse cardiovascular events [50]. This evidence concerns the gene GCG and acute coronary syndrome.