Merely to NGF interaction in tumor cells, Zhu and coworkers highlighted that the NGF–trkANGFR interaction influences growth and spread of pancreatic cancer cells, Zhang and coworkers highlighted the prognostic value of NGF-receptors while Missale and coworkers showed the NGF-receptor overexpression associated with a good prognosis [39–41]. This evidence concerns the gene NGFR and familial pancreatic carcinoma.