MSRA and Insulin resistance: As an example, transgenic mice with an increase in cytosolic (Sod1) or mitochondrial (Sod2) superoxide dismutase, those with an increase in catalase targeted to the mitochondria (mCAT), an increase in peroxiredoxin (Prdx3), those with an increase in cytosolic thioredoxin (Trx1), and those with an increase in mitochondria-targeted methionine sulfoxide reductase A (TgMito MsrA) have all been shown to be protected against the development of insulin resistance when fed high fat diets [53,58,73,90,91,92].