In a study by Jiang et al., three proteins out of 60 were found to be differentially expressed between PCa and adjacent benign tissues using 2DE-DIGE (PTEN, SFPQ and HDAC1) were evaluated by both ELISA and immunohistochemistry and shown to have a significant association with PCa [128]. The gene discussed is HDAC1; the disease is posterior cortical atrophy.