TERT and neoplasm: It was initially hypothesized that the TERT promoter mutation should occur more frequently in tumor types exhibiting high rates of alternating-lengthening of telomere (ALT), however, Killela et al. showed that TERT promoter mutations occur frequently in glioblastomas while rarely in pancreatic neuroendocrine tumors, despite both of them with high rate of ALT [7].