AKT1 and cancer: Recently, Ptk7 was implicated in cancer cell motility and metastasis in fibrosarcoma HT1080 cells, identified as a potential diagnostic biomarker for a variety of cancer types [54,55,56,57,58,59,60,61,62], and proposed as a tumor suppressor gene by inhibiting ERK and AKT phosphorylation in lung cancer [39].