Our current study showing serine/threonine kinases phosphorylation sites in Cameroon Tat sequences suggests that CK2 modulates the signaling and biological activity of Tat during infections with HIV-1 CRF02_AG, CRF37_cpx, CRF01_AE, and subtype G by phosphorylating S61 and/or S62; that PKA modulates the signaling and function of Tat during infections with HIV-1 CRF02_AG, CRF13_cpx, CRF22_01A1, and CRF01_AE by phosphorylating T58, T59 or S59; and that PKC modulates the signaling and biological activity of Tat during infections with HIV-1 CRF11_cpx by phosphorylating S60 and S62. This evidence concerns the gene TAT and infection.