HLA-B and AIDS: This high polymorphism and population differences in HLA would influence the immune response to a pathogen, and there is evidence that some alleles of HLA class-I are associated with specific HIV-1 subtypes [17,18], and that some HLA genotypes such as HLA-B*5802 are associated with high viral loads and faster progression to AIDS [19,20], while others such as B*2705 and B*5701 are associated with stronger immune control and slower disease progression [21,22,23].