Considering the importance of N-myristoylation in HIV subcellular location, viral assembly, transmission and replication [75,76,77,78,79]; as well as the importance of N-myristoylation of HIV proteins in signaling, inflammation, and progression to AIDS [79,80,81]; the increased number of N-myristoylation motifs in CRF02_AG, CRF22_01A1, and subtype D isolates could suggest enhanced Tat function in those viral subtypes. This evidence concerns the gene TAT and AIDS.