Given that RIG-I is the key sensor for recognizing IAV infection in epithelial cells, a major cell type targeted by the virus, and the importance of type I IFN in controlling viral infection and modulating DC-T cell functions, we investigated if the RIG-I-MAVS signaling pathway modulates DC activation and T cell function in RIG-I deficient (RIG-I-/-) mice. Here, RIGI is linked to viral infectious disease.