IL1B and Cowden syndrome 1: When subretinal MP accumulation was induced using a light-challenge (Hu et al., 2015), we observed CS degeneration, similar to the results we obtained with Mos in vitro Furthermore, inhibition of IL-1β, induced in these experimental conditions (Hu et al., 2015), prevented the CS degeneration in vivo, in accordance with the observation that IL-1β potently induced CS degeneration in vitro.