EGF and cancer: This feature renders heparin responsible for its interactions with a variety of growth factors and cytokines, such as fibroblast growth factor (FGF), epidermal growth factor (EGF), insulin growth factor (IGF) and tissue necrosis factor alpha (TNF-α), allowing them to influence cancer cells’ functions, such as invasion and migration and crucial for the initiation and progression of metastasis, epithelial-to-mesenchymal transition (EMT) (Afratis et al. 2012).