Preliminary studies demonstrated that LY294002, a first-generation, weak inhibitor of PI3K pathway that has off-target liabilities [45], destabilized MYCN and could partially inhibit the growth of MYCN-driven neuroblastoma tumors [46] but its use was limited by the off-target toxicity profile of LY294002, which restricted in vivo dosing. Here, MYCN is linked to neuroblastoma.