MYCN and neoplasm: To further confirm the efficacy of NVP-BEZ235 as a therapeutic for MYCN-amplified neuroblastoma in patients, we performed an in vivo preclinical trial using a primary xenograft model in which tumor tissue from a patient (SFNB-08) with high-grade, MYCN-amplified neuroblastoma was implanted orthotopically into the kidney capsule.