Therefore, expression of MYCN is a marker of sensitivity to NVP-BEZ235 treatment in pediatric cell lines and confers sensitivity equivalent to that of adult cell lines mutated in PTEN or PIK3CA. Taken together, the implication is that expression of MYCN is a marker of sensitivity to PI3K/mTOR pathway inhibition in neuroblastoma cells. This evidence concerns the gene MYCN and neuroblastoma.