We first wished to demonstrate clinically relevant activity of IB in CML cells, so primary CD34+ CML-CP cells and BCR-ABL1+ human CML-BC cell lines were incubated with the drug in vitro and total viable cell counts performed by Trypan Blue dye exclusion after 72 h. This evidence concerns the gene CD34 and chronic myelogenous leukemia, BCR-ABL1 positive.