PTPA and chronic myelogenous leukemia, BCR-ABL1 positive: Mechanistically, we found that IB acts as a potent PAD [8] as it was capable of strongly reactivating the enzymatic activity of the PP2A tumor suppressor that, reportedly, is inactive in both CML quiescent stem and proliferating progenitor cells [7, 19], and so inhibiting NF-κB [15, 27].