Primary CD34+ CML-CP cells were more resistant to apoptosis induction by IB than BCR-ABL1WT+ CML-BC cell lines, nonetheless, the percentage of Annexin V+ cells increased in a concentration dependent manner in response to IB (Figure 2A–2C), and to a magnitude far greater than can be achieved with TKI. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.