Furthermore, both PDXs and the original tumors exhibited conserved genomic DNA alterations including both EGFR amplification and PTEN deletion (Figure 5C–5E) as well as EGFR, p-EGFR, PTEN, p-SRC, and p-AKT expression correlating with that of the parental tumor (Figure 5F). Here, AKT1 is linked to neoplasm.