Prior to the analysis, we demonstrated the urothelial origin of the tumor cells through hematoxylin-eosin (H&E) staining and immunohistochemistry (IHC) analysis for cytokeratin (CK) 7, pan-CK, Ki-67, CK20, and desmin (Figure 1B) [16, 17]. The gene discussed is DES; the disease is neoplasm.