Notably, one group of genes with very strong negative correlations (≤-0.9, Supplementary Table S2) to radiomic features were found to be associated with the AR signaling genes: KLK2, KLK3, HOMER2, BMPR1B, or belong to validated prostate cancer classifiers: [4, 14] CHRNA2, MT1H, DPP4, MYBPC1. Here, CHRNA2 is linked to Familial prostate cancer.