We have recently reported that diabetogenic variants influence MM risk [47] and recent genome-wide association studies (GWAS) have also suggested the involvement of genetic variants within the MTHFD1L, AKAP12 and FOPNL loci in determining MM patient survival [39, 44, 45] but also an indirect implication of diabetogenic genes such as TCF7L2 [45]. Here, TCF7L2 is linked to Miyoshi myopathy.