In line with this, it has been also suggested that HNF1B may induce impaired glucose tolerance and attenuated insulin sensitivity in a miRNA-dependent manner [60], which might lead to an enhanced insulin secretion and the activation of the IGF1 pathway, an important factor mediating myeloma cell growth, proliferation and cell maturation [27, 59, 61]. This evidence concerns the gene IGF1 and plasma cell myeloma.