HNF1B and cancer: Nonetheless, given that HFN1B contains multiple independent SNPs or haplotypes that have been associated with HNF1B mRNA expression [55, 56] and methylation [57] levels but also with the risk of developing several types of cancer [55–57], it seems to be reasonable to consider the possibility that other SNPs within this locus and showing a stronger association with OS could explain better the link between the HNF1B and clinical outcome.