Considering all the above but also the fact that the association of the HNF1Brs7501939 SNP with OS was driven by a non-diabetogenic (T) allele that does not affect HNF1B mRNA expression, we hypothesize that the effect of this variant to contribute to tumour progression in MM might be mediated by a non-insulin-dependent mechanism. Here, INS is linked to Miyoshi myopathy.