However, given the consistency of the overall or gender-specific associations observed for BCL11A, MADD, PRC1, PROX1, SLC2A2 and TCF7L2 SNPs with OS across the populations tested and considering that gender-specific genetic alterations might influence MM survival [48], we suggest that these variants might also exert a modest effect to modulate patient survival. Here, PROX1 is linked to Miyoshi myopathy.