IGF-1 stimulated phosphorylation of the type I IGF receptor and Akt in all the gastric cancer cell lines analyzed which demonstrates that the IGF signal transduction pathway is active in cells that overexpress HER2, FGFR2 or MET. A recent study of NCI-N87 suggested that activity of the IGF signal transduction pathway confers lapatinib resistance [18]. The gene discussed is ERBB2; the disease is gastric cancer.