IL6 and Sepsis: Reduced cytokine and chemokine concentrations in plasma of C5-/- mice in present DH model of blunt chest trauma and polymicrobial sepsis (Fig 1) are in accordance with earlier studies which showed diminished plasma levels of pro-inflammatory mediators such as Il-6 and MCP-1 and anti-inflammatory mediators such as IL-1 receptor antagonist (IL-1Ra) and IL-10 in C5-/- mice 24 hrs after intermediate-grade CLP-induced sepsis associated with greatly impaired bacterial clearance [7].