The 425 patients had a prostate volume of 71.14 cc, an average age of 66.86 years (±8.11), and PSA mean of 22.13 ng/mL; they were stratified by BMI, presenting normal weight 19.04%, overweight 54.76%, obesity grade I 20.23%, and obesity grade II 5.95%; in conclusion of this, 80.92% of our patients have some degree of overweight or obesity and 36.90% have diabetes mellitus; then they were randomly divided in two groups. The gene discussed is KLK3; the disease is obesity due to melanocortin 4 receptor deficiency.