L. monocytogenes, a Gram-positive bacterium causing infections in immune-compromised patients and pregnant women [10], mainly recognizes TLR-2 and the TLR-2 dependent signaling as PI3K and Rac 1, and this mechanism is involved in the phagocytosis of L. monocytogenes by macrophages [11]. The gene discussed is TLR2; the disease is infection.