HIF1A and neoplasm: Lee et al. [92] showed that hypoxia-driven HIF1α expression and stabilization occurred in the early growth stages of both murine KrasG12D PDAC and human PDAC tumors, and that the deletion of pancreas-specific Hif1α in mice harboring KrasG12D tumors resulted in accelerated tumor growth and was associated with an influx of intra-pancreatic B cells.