HIF1A and neoplasm: B-cell depletion in KrasG12D/HIF1α-KO mice following treatment with α-CD20 mAb significantly decreased the number of grade 3 PanIN lesions and reduced the percentage of mice with microinvasive lesions, indicating that the accelerated tumor growth in HIF1α-KO mice is due at least in part related to increased intrapancreatic B-cell recruitment.