Consistent with the finding that CD19+CD25+ tumor-evoked Bregs (tBregs) constitutively express Stat3 and promote tumor growth and metastasis by TGFβ-dependent conversion of non-Tregs to Tregs [5], Lee-Chang et al. [73] demonstrated that treatment with non-cytotoxic doses of resveratrol (RSV), a potent inhibitor of Stat3 phosphorylation, suppressed proliferation of tBregs and FoxP3+ Tregs in vitro, and inhibited growth of B16 and 4 T1 murine tumors in vivo. The gene discussed is TGFB1; the disease is neoplasm.