HSP90B1 and neoplasm: In EL-4 thymoma implanted mice, Oizumi et al. [68] demonstrated using a highly immunogenic secreted form of gp96 heat shock protein as a vaccine, that effective tumor antigen-specific gp96-chaperone vaccination was achieved with a single vaccination in BCDM, while repeated vaccinations were required to achieve a similar level of immunity in WT mice.