SCID mice injected with human MHCC-97 L HCC cells mice together with human CD19+CD24+CD38+ Bregs demonstrated markedly larger tumor growth at 6 weeks and increased serum IL-10 levels compared to SCID mice injected with HCC cells and CD19+CD24−CD38− non-Bregs. Here, CD38 is linked to hepatocellular carcinoma.