Consistent with the hypothesis that TIL-Bs may have an anti-tumor effect when co-localized with CD8+ T cells, Kroeger et al. [10] showed that TIL-B- and T-cells co-localize and arrange in tertiary lymphoid structures (TLS) surrounded by dense IgG+ plasma cell infiltrates in HGSC tumors. Here, CD8A is linked to neoplasm.