It was not surprising that IPA analysis of Txnip protein interactions identified cellular growth and proliferation as a major predicted functional pathway based on known interactions (Table 2). Txnip-deficient fibroblasts proliferate more rapidly than wild-type counterparts [35] and the HcB-19 strain (spontaneous Txnip mutation) has increased incidence of hepatocellular carcinomas [36]. The gene discussed is TXNIP; the disease is hepatocellular carcinoma.