In fact, focusing each single GIST oncogenic mutation arousal (counting each KIT-mutant kindred as one): 1) mutations involve exon 9 in 1/37 (3 %) and exon 17 in 4/37 (11 %) cases; 2) among exon-11 mutations, substitutions (61 %) prevail over deletions and insertion/deletions (29 %) (reversing the 31 %/60 % proportion found in sporadic GISTs); 3) KIT exon-11 mutations appear enriched in p.V559A, p.W557R and p.L576P substitutions (48 %, versus 10 % of sporadic GISTs) [58]. Here, KIT is linked to gastrointestinal stromal tumor.