First diagnoses of IFP (including tumors misdiagnosed as neurofibromas) tend to precede those of GIST (means 40.6 and 48.1 years, respectively, p = 0.12 -Mann–Whitney U Test-) in PDGFRA-mutant syndrome, suggesting a faster IFP tumorigenesis (of note, IFP and GIST are unrelated lesions) [45, 47, 48, 71, 72, 78]. Here, PDGFRA is linked to Down syndrome.