Moreover, a germline PDGFRA-mutant individual bearing multiple IFPs (and a likely PDGFRA-unrelated GIST hosting a somatic KIT mutation) has been reported very recently [72]; this individual shares both germline defect and geographical origin with one of the above mentioned kindreds [48], and is therefore probably related to it. The gene discussed is PDGFRA; the disease is gastrointestinal stromal tumor.