PFKFB3 and acute lymphoblastic leukemia: Since the reduction in cortical protrusion formation was similar in isPFKFB3KD-FIL/COR and isPFKFB3KD-ALL cells (Supplementary Fig. 2b) and as the competitiveness of isPFKFB3KD-ALL cells was higher (Fig. 4b), cortical protrusion formation was not expected to contribute to the PFKFB3-driven effect on cellular heterogeneity in the DAPT-treated sprout.