Severe osteoblastic defects were found in a model of myeloid blast-crisis chronic myeloid leukemia (CML, driven by BCR-ABL;Nup98/HoxA9), with decreased osteoprogenitors, endosteal-lining osteoblasts and bone mass, associated with increased CCL3 expression [72]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.