LPCAT1 and Schnyder corneal dystrophy: Altogether, we provided strong evidence that overexpression of LPCAT1 specifically in BMCs leads to increased erythrocyte LPACT1 activity, in turn decreases LysoPC and increases PC membrane contents in the SCD mouse erythrocytes and decreases circulating AA and eventually attenuates sickling, hemolysis, inflammation and tissue damage in SCD mice.