GSK3B and schizophrenia: Since patients with novel variants in the CREB1 gene experienced the positive symptoms of schizophrenia27, our data suggests that activation of CREB1 via the Akt-GSK3β pathway in the NAc is very likely to be associated with the therapeutic effects of aripiprazole and haloperidol on the positive symptoms of schizophrenia (Fig. 7C).