To check whether the Crb3/Hippo/YAP mechanism is involved in these diseases we investigated a naturally occurring mouse line, Dy2j/2j, mutated on α2 laminin gene that displays a peripheral neuropathy with reduced internodal length32 (Fig. 8a) mimicking the human congenital neuro-muscular dystrophy 1A (ref. 9). Here, LAMB2 is linked to peripheral neuropathy.