TNFRSF1A and primary biliary cholangitis: GWASs have identified associations between PBC and genomic loci near LTBR/TNFRSF1A and NFKB1 (Additional file 3) [76] but the genetic associations with the NF-κB inhibitor kinase subunits CHUK and IKBKB that we describe here have not been previously established.