Mutations in TNFRSF members can also lead to common variable immunodeficiency (CVID): approximately 9 % of patients carry one or two variant alleles of TNFRSF13B (encoding TACI) [10] and a few patients carry biallelic mutations of TNFRSF13C (encoding BAFF-R) [11]. The gene discussed is TNFRSF13B; the disease is common variable immunodeficiency.