BRCA2 and neoplasm: BRCA1 and BRCA2 are tumor suppressors that are commonly mutated or depleted in hereditary and sporadic breast cancers, and have important roles in homologous recombination (HR) (Prakash et al., 2015), a template directed pathway that accurately repairs DNA lesions affecting both strands of the DNA duplex (Couedel et al., 2004; Moynahan and Jasin, 2010; Jasin and Rothstein, 2013; Kowalczykowski, 2015; Heyer, 2015).