NCAM1 and cancer: The CD56 target is a marker for natural killer cells, certain forms of cancer, is associated with cell migration and invasion, and is the target for the ADC known as IMGN901.41,42 Finally, CD147 has been linked to a number of important cancers and has been found to induce the expression of matrix metalloproteinases as well as the lactate transporters MCT1 and MCT4.43 Clearly more targets will be identified as this work progresses but the list so far shows great promise at targeting CGs and other molecules that act on extracellular membrane targets.