The concept that sRAGE levels may be elevated in response to serum AGE levels and reflect tissue RAGE expression in diabetes is supported by similar elevations in levels of ICAM-1 and VCAM-1 under the same circumstances since RAGE belongs to the same immunoglobulin superfamily as ICAM-1 and VCAM-1 [34]. The gene discussed is VCAM1; the disease is diabetes mellitus.