A previous study, based on a heterologous assay system employing human breast cancer cells and murine embryonic fibroblasts (MEFs), has shown that the highly invasive MDA-MB-231 cells were able to induce SDC1 expression in MEFs, while several low-invasive breast cancer cell lines (e.g. MCF-7) had no effect, whatsoever. Here, SDC1 is linked to breast carcinoma.