ITIH4 and infection: This was significantly greater distances than that observed in RV144, where the mean gp120 amino acid sequence distance between the CRF01_AE viruses from breakthrough infections in the placebo arm to the clade-matched vaccine immunogen, CM244 was 15.24% (95% CI 14.69%–15.79%) (Ce1086 and TV1 individually both to CM244 p<0.0001) (Fig 8A).