Indeed the preliminary analyses of LATS2-dependent H3K27me3 module which was obtained by ChIP-seq of LATS2 KO HeLa-S3 cells and cancer genomics data from TCGA (The Cancer Genome Atlas) cohorts, suggest the possibility of LATS2 –PRC2 axis in mammalian nervous system including tumorigenesis (Discussed in detail in S1 File). Here, LATS2 is linked to cancer.