Thus far it has been thought that inhibiting the MDM2/HIF-1alpha interaction would result in tumor cell death in hypoxia [147] but recently Joshi et al. [84] found that MDM2 causes HIF-1alpha to be degraded during hypoxia so inhibiting the MDM2/HIF-1alpha interaction may actually result in tumor growth, not death. Here, MDM2 is linked to neoplasm.