This upregulated stromal expression of endosialin has been reported in a wide range of human cancers, including breast carcinomas (Rouleau et al, 2008), ovarian epithelial, colonic and rectal carcinomas (Bagley et al, 2008), small cell lung cancer, neuroblastoma and melanoma (Rouleau et al, 2011), metastatic melanomas and squamous cell carcinomas (Huber et al, 2006), high grade gliomas/glioblastoma multiforme, anaplastic astrocytomas and metastatic carcinomas to brain (Brady et al, 2004; Simonavicius et al, 2008). This evidence concerns the gene CD248 and melanoma.