CD248 and neoplasm: However, examination of a range of human cancers, although confirming this stromal upregulation of endosialin, has demonstrated that its expression is confined to stromal fibroblasts and pericytes of tumour vasculature rather than endothelium (MacFadyen et al, 2007; Rouleau et al, 2008; Simonavicius et al, 2008).