Regarding the latter, Rouleau et al assessed the immunohistochemical expression of endosialin on 86 formalin-fixed, paraffin-embedded human clinical sarcoma specimens (Rouleau et al, 2008), and documented expression in different cell types; 51% (54/86) showed endosialin expression in malignant cells, 78% (67/86) in vasculature and 22% (19/86) in stromal cells. This evidence concerns the gene CD248 and sarcoma.