CD248 and sarcoma: While further work is required in assessing endosialin expression in other sarcoma types, particularly to further explore the differential expression of endosialin on differentiated vs less differentiated sarcomas, this study suggests that endosialin may be of potential use as an ancillary diagnostic aid in three ways: first, as a putative marker of ‘mesenchymal' lineage, second in discriminating pleomorphic sarcomas from poorly differentiated non-mesenchymal neoplasms and finally as a potential marker of the progressive ‘undifferentiation' of mesenchymal tumours.