In this regard, it can be mentioned that BCL2A1 interacts with the BH3-like protein Beclin-1, thus potentially contributing to the inhibition of autophagy [52] and that Beclin-1-deficient mice fail to mount autoreactive T-cell responses and are resistant to experimental autoimmune encephalomyelitis in association with a reduction in TH17 and TH1 cells [53]. The gene discussed is BCL2A1; the disease is experimental autoimmune encephalomyelitis.