NOS3 and endothelial dysfunction: These are widely distributed in several tissues, particularly in endothelial cells, where they mediate vasodilation and antioxidant and antithrombotic effects [99]. In vitro and in vivo studies indicate that CRP may interfere with NO synthesis by inhibiting endothelial nitric oxide synthase (eNOS) activity through various pathways, all of which ultimately lead to endothelial dysfunction [100].