Indeed, both hypoadiponectinemia and hyperleptinemia, two adipokine disturbances common in subjects with obesity and insulin resistance, have been linked to increased hepatic production of CRP [20, 21], as well as augmented in situ synthesis of CRP in vascular endothelial cells in hyperleptinemia [22]. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.