A high-density single nucleotide polymorphism (SNP) screening of MHC in SLE demonstrated strong evidence for independent susceptibility regions, including rs3828903 within MICB, in a Caucasian population [6]. MICB belongs to a family of genes located in the MHC class I region, which encodes a stress-induced molecule involved in both innate and adaptive immunity. The gene discussed is MICB; the disease is systemic lupus erythematosus.