The results of coexpression analysis coupled to ENCODE ChIP-Seq data strongly suggest c-Myc and C/EBPβ as regulators of the expression of key enzymes of polyamine metabolism that are upregulated in colorectal cancer: SMOX, AZIN1, MTAP, SRM, AMD1, ODC1, and AGMAT. This evidence concerns the gene CEBPB and colorectal cancer.