EGFR and neoplasm: In patients pretreated with chemotherapy and erlotinib or gefitinib, dacomitinib compared to placebo did not increase OS neither in patients with EGFR-mutation-positive tumours (HR 0.98, 95% CI 0.67–1.44) nor in patients with EGFR wild-type tumours (HR 0.93, 0.71–1.21; pinteraction = 0.69) [24].