Studies in macrophages and various animal models demonstrated that the activation of NLRP3 inflammasome can be observed in kinds of autoimmune and inflammatory diseases such as experimental autoimmune encephalomyelitis (EAE) [33], multiple sclerosis [34], inflammatory bowel disease including ulcerative colitis, and Crohn's disease [35, 36]. This evidence concerns the gene NLRP3 and multiple sclerosis.