As shown in the lower panel of Fig. 6D, half of the recipients of Evi1-expressing Eed+/Δ cells (Eed+/Δ + Evi1-IRES-EGFP) developed acute leukemia, whereas none transplanted with Evi1-expressing control cells (Ctrl + Evi1-IRES-EGFP) exhibited hematopoietic abnormalities (p < 0.05). This evidence concerns the gene EED and acute leukemia.