For example, downregulation of Junb (Eed+/Δ/control = 0.12) is causative for myeloid leukemia, and suppressed expression of Bcl11b and Tcf3 (E2A) (Eed+/Δ/control = 0.25 and 0.28, respectively) is involved in the development of T-ALL (DRX046261 and DRX046262 in the DDBJ (DNA Data Bank of Japan) BioSample)35, 36, 37. The gene discussed is JUNB; the disease is acute lymphoblastic leukemia.