A number of LRRK2 pathogenic mutations have been linked to familial Parkinson's disease analysis; depending on the cellular context, these mutations have been reported to have wide ranging effects on LRRK2 function from gain-of-function mutations to dominant negative and loss-of-function5, 8, 24, 25, 26, 27. The gene discussed is LRRK2; the disease is Parkinson disease.