EGFR and non-small cell lung carcinoma: Overexpression of antiapoptotic Bcl-2 family members such as Bcl-2, Bcl-xl, and induced myeloid leukemia cell differentiation protein Mcl-1 (Mcl-1) has been identified in a number of EGFR TKIs resistance NSCLC cell lines and is considered as a therapeutic target for reversing the resistance.