Human inflammatory DCvivo, but not inflammatory macrophagesvivo, from tumour ascites and synovial fluids of arthritis patients are able to secrete both IL-12p70 and IL-23 when activated with different combinations of Pam3CSK4 (a synthetic triacylated lipoprotein which is a TLR1/2 agonist), CD40L, and IFN-γ35. This evidence concerns the gene TLR1 and arthritic joint disease.