Lipid profiling revealed a correlation between plasma HNP 1–3 levels in normal and hyperlipidemia patients as indicated by TC (r = 0.530, p = 0.024) and LDL (r = 0.525 p = 0.030), but not by HDL (r = −0.870, p = 0.714) and TG (r = 0.088, p = 0.721) levels. Here, DEFA1 is linked to hyperlipidemia.