CLCN7 and osteoporosis: Nevertheless, gene ablation of either Clc-6 or Clc-7 led to lysosomal storage and neurodegeneration (Kasper et al., 2005; Poët et al., 2006); either deleting the Clc-7 gene or specifically uncoupling its H+ and Cl− conductance impaired bone resorption and caused osteoporosis (Kornak et al., 2001; Weinert et al., 2010).