The small nuclear ribonucleoprotein polypeptide N (SNRPN) gene, encoding the RNA-binding SmN protein, is located within chromosome 15q11-q13 in the region associated with various neurodevelopmental disabilities such as Prader-Willi syndrome (PWS), Angelman syndrome (AS) and autism spectrum disorders (ASDs)1, 2, 3. The gene discussed is SNRPN; the disease is autism spectrum disorder.