TGFB1 and pulmonary fibrosis: An independent imaging-based screen for lung adenocarcinoma EMT inhibitors identified methacycline, a compound that interfered with specific MAPK pathways acting downstream of TGF-β; in vivo, methacycline blocked the lung fibrosis induced by bleomycin, without perturbing central responses to TGF-β signalling in various stromal cell types28.